Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has either Harvested or Rescued every possible Little Sister

Successfully invent at least 100 items

The player has taken a picture of Sander Cohen's corpse

The player has defeated Atlas

Purchased every slot in all four Plasmid and Tonic tracks

The player has broken Fontaine's mind control

The player has fully upgraded three weapons

Fully research the Little Sister

Hit the jackpot at a slot machine

Fully research the Bouncer

The player has fully researched the Spider Splicer

The player has restored the forests of Arcadia