The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has become a Big Daddy

The player has broken Fontaine's mind control

The player has entered Sander Cohen's personal quarters

The player has fully upgraded three weapons

Take at least one photo in every research group

The player has restored the forests of Arcadia

The player has successfully invented at least one item

The player has acquired at least one weapon upgrade

The player has taken a Research Photo of the highest grade

The player has purchased one slot in any Plasmid or Tonic track

The player has successfully hacked a safe