Play 20 MyBuzz!™ games

Shoot 50 objects using Kinesis

Score over 3000 points in a singleplayer game

Play one MyBuzz!™ game

Dismember 20 Limbs

The player has defeated Atlas

The player has either Harvested or Rescued every possible Little Sister

Purchased every slot in all four Plasmid and Tonic tracks

Fully upgrade four weapons

The player has successfully invented all possible ammo types

The player has defeated Andrew Ryan

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has taken a picture of Sander Cohen's corpse