Rescued the Little Sister in “Worlds of Hurt” using only plasmids, tonics, the wrench, and the research camera, on Medium or higher difficulty

Found all collectable Roses in “A Shocking Turn of Events”

Rescued the Little Sister in “A Shocking Turn of Events”

Defeat 250,000 Monsters

Rescued the Little Sister in “The ‘I’ in Team” in under 3:00

Rescued the Little Sister in “Worlds of Hurt”

Rescued the Little Sister in “The ‘I’ in Team”

The player has become a Big Daddy

Acquire all upgrades for all weapons

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has broken Fontaine's mind control

The player has taken a picture of Sander Cohen's corpse

The player has successfully invented all possible ammo types