Bought one Plasmid or Tonic Slot at a Gatherer's Garden.

Adopted a new Little Sister for the first time.

Defended yourself against Lamb's assault in the train station.

Found your way back into the ruins of Rapture.

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has fully upgraded three weapons

The player has fully upgraded two weapons

The player has defeated Andrew Ryan

The player has completed Sander Cohen's great masterpiece

The player has restored the forests of Arcadia

The player has successfully hacked a safe

The player has acquired at least one weapon upgrade