The player has either Harvested or Rescued every possible Little Sister

Fully upgrade four weapons

The player has fully upgraded three weapons

The player has defeated Andrew Ryan

The player has fully upgraded two weapons

Purchased every slot in all four Plasmid and Tonic tracks

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has successfully invented all possible ammo types

The player has fully upgraded one weapon

The player has successfully completed 50 hacks

The player has acquired at least one weapon upgrade

The player has taken a Research Photo of the highest grade

The player has purchased one slot in any Plasmid or Tonic track