Shoot all of Amsel's henchmen, including their attack dog, without reloading. (Solo only)

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has acquired at least one weapon upgrade

The player has defeated Peach Wilkins

Get 150 kills with the Carbine 40mm, LAARK, or frag grenade in the single player Campaign.

The player has taken at least one Research Photo of a Splicer

The player has defeated the crazed Dr. Steinman

The player has successfully hacked a security camera

The player has successfully hacked a vending machine

The player has performed at least one successful hack

The player has shocked an enemy in the water

Get 30 headshots while scoped in with the Fareye or Marksman in the single player Campaign.

Kill 50 enemies through solid matter with the Auger in the single player Campaign.