The player has become a Big Daddy

The player has either Harvested or Rescued every possible Little Sister

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has broken Fontaine's mind control

The player has defeated Andrew Ryan

The player has successfully invented all possible ammo types

Fully research the Bouncer

Take at least one photo in every research group

The player has fully researched the Spider Splicer

Fully research the Rosie

The player has fully upgraded one weapon

The player has fully researched the Thuggish Splicer

The player has acquired at least one weapon upgrade