Make it to the police station.

Escape from the sewers.

Use Wooden Boards to board up a window.

Shoot the grenade you fed to an enemy.

Customize a weapon.

Counterattack with a sub-weapon.

Clear the game without opening the item box.

Open a portable safe.

Complete Leon's story on "Hardcore" game mode.

Complete the game without using a recovery item.

Complete Leon's story on "Standard" or "Hardcore" with an S rank.

Open all of the safes and locks in the game.