Discover the Shrine in the Catacombe di Roma.

Throw money in a well.

Access your email in 2012.

Achieve 100% Synchronization in any Sequence other than Sequence 1.

Find a secure place to hide and re-enter the Animus.

Attempt to access DNA Sequence 9 for the first time.

Obtain all the Trophies.

Gather all "Letters of the Lost".

Gather a total of 60 relics.

Craft a special syringe.

Attend the final ceremony.

Complete Riley's interrogation.