Max out all possible research

The player has purchased every slot in one of the Plasmid or Tonic tracks

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

Fully research the Little Sister

The player has successfully invented all possible ammo types

The player has fully researched the Spider Splicer

The player has restored the forests of Arcadia

The player has fully upgraded one weapon

The player has fully researched the Thuggish Splicer

The player has acquired at least one weapon upgrade

The player has fully researched the Leadhead Splicer

The player has successfully hacked a vending machine