Synthesize 300 rooms.

The player has successfully invented all possible ammo types

The player has entered Sander Cohen's personal quarters

Max out all possible research

Purchased every slot in all four Plasmid and Tonic tracks

Fully research the Little Sister

The player has fully upgraded three weapons

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has fully upgraded two weapons

Fully research the Rosie

The player has successfully invented at least one item

The player has fully researched the Thuggish Splicer

The player has fully researched the Leadhead Splicer