Fully upgrade four weapons

The player has entered Sander Cohen's personal quarters

The player has fully upgraded three weapons

Take at least one photo in every research group

Fully research the Houdini Splicer

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has fully researched the Spider Splicer

The player has fully researched the Leadhead Splicer

The player has fully researched the Thuggish Splicer

The player has acquired at least one weapon upgrade

The player has successfully completed 50 hacks

The player has taken a Research Photo of the highest grade

The player has defeated the crazed Dr. Steinman