The player has defeated Atlas

The player has either Harvested or Rescued every possible Little Sister

The player has fully upgraded three weapons

The player has defeated Andrew Ryan

The player has fully upgraded two weapons

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has fully upgraded one weapon

Completed "Galaxy News Radio"

The player has acquired at least one weapon upgrade

The player has taken at least one Research Photo of a Splicer

The player has successfully hacked a security camera

The player has defeated the crazed Dr. Steinman