Complete Leon's story.

Escape the police station.

Complete Ada's segment.

Complete Sherry's segment.

Open all of the safes and locks in the game.

Solve the Goddess Statue puzzle.

Kill 10 enemies in a row using only Gauntlet after obtaining the Revolver

Complete a run while holding 20 trinkets using Jules

Reach the Nest for the first time.

Reach the Bank for the first time.

Get the Leghugger to evolve

Free the passage under the stairs in Transidor for Ridmi