Fully research the Nitro Splicer

The player has defeated Andrew Ryan

The player has taken a picture of Sander Cohen's corpse

The player has purchased every slot in one of the Plasmid or Tonic tracks

Take at least one photo in every research group

The player has successfully invented all possible ammo types

Hit the jackpot at a slot machine

Fully research the Rosie

The player has fully upgraded one weapon

The player has successfully completed 50 hacks

The player has acquired at least one weapon upgrade

The player has fully researched the Leadhead Splicer

The player has taken at least one Research Photo of a Splicer