The player has fully upgraded three weapons

The player has taken a picture of Sander Cohen's corpse

The player has defeated Andrew Ryan

The player has purchased every slot in one of the Plasmid or Tonic tracks

Fully research the Houdini Splicer

Take at least one photo in every research group

The player has fully upgraded one weapon

The player has fully researched the Leadhead Splicer

The player has acquired at least one weapon upgrade

The player has purchased one slot in any Plasmid or Tonic track

The player has taken a Research Photo of the highest grade

The player has successfully hacked a security camera

The player has successfully hacked a safe