The player has become a Big Daddy

The player has either Harvested or Rescued every possible Little Sister

Purchased every slot in all four Plasmid and Tonic tracks

Fully upgrade four weapons

Stomped five Minions to death.

Complete game using Truth Door.

Release Jeff from his Trap.

First kill with a Hatchet.

First kill with a Scalpel.

First kill with Scissors.

First kill with a Gas Mine.

First kill with a Stun Mine.