The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has broken Fontaine's mind control

Fully research the Nitro Splicer

The player has defeated Andrew Ryan

Fully research the Bouncer

The player has completed Sander Cohen's great masterpiece

Take at least one photo in every research group

The player has restored the forests of Arcadia

Fully research the Houdini Splicer

The player has fully researched the Thuggish Splicer

The player has successfully invented at least one item

The player has acquired at least one weapon upgrade

The player has fully researched the Leadhead Splicer