The player has broken Fontaine's mind control

The player has entered Sander Cohen's personal quarters

Fully upgrade four weapons

Max out all possible research

The player has defeated Andrew Ryan

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has fully upgraded two weapons

The player has successfully invented all possible ammo types

Take at least one photo in every research group

The player has fully upgraded one weapon

The player has fully researched the Spider Splicer

Fully research the Rosie

The player has acquired at least one weapon upgrade