Complete the game on Survivor difficulty

The player has completed the game without harvesting any Little Sisters

The player has either Harvested or Rescued every possible Little Sister

Purchased every slot in all four Plasmid and Tonic tracks

The player has broken Fontaine's mind control

The player has fully upgraded three weapons

Fully research the Little Sister

The player has fully upgraded two weapons

The player has completed Sander Cohen's great masterpiece

The player has successfully invented all possible ammo types

Hit the jackpot at a slot machine

The player has purchased every slot in one of the Plasmid or Tonic tracks

Fully research the Houdini Splicer