Fully upgrade five weapons

Take at least one photo in every research group

The player has broken Fontaine's mind control

The player has successfully invented all possible ammo types

The player has defeated Andrew Ryan

Fully research the Bouncer

The player has taken a picture of Sander Cohen's corpse

The player has fully researched the Spider Splicer

The player has fully upgraded two weapons

The player has fully researched the Thuggish Splicer

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has successfully invented at least one item

The player has defeated Peach Wilkins