Kill 3 living enemies with one drop of a match.

That vision in the hospice... why here? Why now? (Ch. 4)

Kill 30 enemies.

Beat the Caves/Catacombs without taking damage

Beat the Dark Room with Isaac

Kill Isaac with Isaac

Beat the Caves 30 times

Kill Satan with Azazel

Kill Satan with Cain

Kill Isaac with Cain

Beat the Boss Rush

Kill Mom's Heart 5 times

Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball