Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has become a Big Daddy

The player has either Harvested or Rescued every possible Little Sister

Fully upgrade five weapons

The player has broken Fontaine's mind control

The player has entered Sander Cohen's personal quarters

The player has fully upgraded two weapons

The player has defeated Andrew Ryan

The player has fully upgraded one weapon

Fully research the Bouncer

Fully research the Nitro Splicer

The player has purchased every slot in one of the Plasmid or Tonic tracks

Take at least one photo in every research group