The player has broken Fontaine's mind control

The player has defeated Andrew Ryan

The player has purchased every slot in one of the Plasmid or Tonic tracks

Fully research the Houdini Splicer

The player has fully upgraded one weapon

The player has fully researched the Thuggish Splicer

The player has successfully invented at least one item

The player has acquired at least one weapon upgrade

The player has taken a Research Photo of the highest grade

The player has purchased one slot in any Plasmid or Tonic track

The player has successfully hacked a safe

The player has successfully hacked a vending machine