Bought one Plasmid or Tonic Slot at a Gatherer's Garden.

Defeated the Preacher.

Confronted Lamb's lieutenant in Pauper's Drop.

Defeated 3 Big Daddies without dying during the fight.

Defended yourself against the Big Sister without dying.

Adopted a new Little Sister for the first time.

Eliminate Hyman Roth.

Eliminate four rival families.

Kill Henry Mitchell.

Recruit a full family tree.

Kill 750 mobsters.

Find a level 3 firearm upgrade.