The player has broken Fontaine's mind control

Max out all possible research

The player has defeated Andrew Ryan

The player has fully upgraded three weapons

The player has purchased every slot in one of the Plasmid or Tonic tracks

Take at least one photo in every research group

The player has fully researched the Spider Splicer

Hit the jackpot at a slot machine

Fully research the Rosie

The player has fully upgraded one weapon

The player has successfully invented at least one item

The player has defeated Peach Wilkins

The player has successfully completed 50 hacks