Installed the third upgrade to a weapon.

Joined forces with Sinclair in Ryan Amusements.

Hacked one of each kind of machine.

Defended yourself against Lamb's assault in the train station.

Used the Hack Tool to hack an object at a distance.

The player has defeated Atlas

Purchased every slot in all four Plasmid and Tonic tracks

The player has either Harvested or Rescued every possible Little Sister

The player has fully researched the Leadhead Splicer

The player has defeated Andrew Ryan

The player has completed Sander Cohen's great masterpiece

The player has successfully invented all possible ammo types

The player has purchased every slot in one of the Plasmid or Tonic tracks