The player has fully upgraded three weapons

The player has completed Sander Cohen's great masterpiece

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has fully researched the Spider Splicer

Fully research the Rosie

Fully research the Houdini Splicer

The player has successfully invented at least one item

The player has purchased one slot in any Plasmid or Tonic track

The player has successfully hacked a security camera

The player has taken a Research Photo of the highest grade

The player has successfully hacked a vending machine

The player has successfully hacked a safe