Beat the Basement 40 times

Kill the Skeleton King.

Make a profit over your total investments in the stock market.

You cleaned out Vangelico to pay back Martin Madrazo.

Beat 2 levels in a row without taking damage

Kill Satan with Judas

Kill Satan with Lazarus

Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball

Kill Satan with Cain

Beat the Basement/Cellar without taking damage

Kill Satan with Isaac

Make 3 deals with the devil in one run

Have 7 or more max red hearts at one time