The player has broken Fontaine's mind control

The player has defeated Andrew Ryan

The player has successfully invented all possible ammo types

The player has purchased every slot in one of the Plasmid or Tonic tracks

Take at least one photo in every research group

The player has restored the forests of Arcadia

The player has fully upgraded one weapon

Fully research the Little Sister

The player has successfully invented at least one item

The player has acquired at least one weapon upgrade

The player has defeated Peach Wilkins

The player has taken at least one Research Photo of a Splicer

The player has defeated the crazed Dr. Steinman