Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

Fully upgrade five weapons

The player has broken Fontaine's mind control

Fully research the Nitro Splicer

Fully research the Little Sister

The player has defeated Andrew Ryan

Fully research the Bouncer

The player has taken a picture of Sander Cohen's corpse

The player has fully researched the Spider Splicer

The player has restored the forests of Arcadia

The player has fully researched the Leadhead Splicer

The player has fully researched the Thuggish Splicer