Win a championship belt in a single weight class.

The player has become a Big Daddy

Fully research the Rosie

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has fully upgraded one weapon

Fully research the Bouncer

The player has successfully invented all possible ammo types

The player has completed Sander Cohen's great masterpiece

Take at least one photo in every research group

Fully research the Houdini Splicer

The player has successfully invented at least one item

The player has defeated Peach Wilkins

The player has taken at least one Research Photo of a Splicer