The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has successfully invented at least one item

Defeat 30 enemies with the RPG - 7

Defeat ten enemies in a row with hand-to-hand combat

Defeat 250 enemies with headshots

Defeat 20 enemies with the Pistole

Defeat 70 enemies with the FAL

Finish the game in Easy Mode

Finish the game in Hard Mode

Defeat 20 enemies by shooting from the hip (without aiming with L1)

Defeat 100 enemies with headshots

Defeat 20 enemies with a single punch, after softening them up with gunfire