The player has become a Big Daddy

The player has either Harvested or Rescued every possible Little Sister

Fully upgrade five weapons

The player has successfully invented all possible ammo types

Fully research the Rosie

Fully upgrade four weapons

The player has fully upgraded three weapons

The player has completed Sander Cohen's great masterpiece

The player has purchased every slot in one of the Plasmid or Tonic tracks

Take at least one photo in every research group

The player has restored the forests of Arcadia

The player has successfully invented at least one item

The player has defeated Peach Wilkins