Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

Max out all possible research

The player has broken Fontaine's mind control

Fully upgrade four weapons

The player has successfully completed 50 hacks

The player has defeated Andrew Ryan

The player has fully upgraded three weapons

The player has completed Sander Cohen's great masterpiece

Take at least one photo in every research group

Obtain all trophies

Fully research the Nitro Splicer

Hit the jackpot at a slot machine

The player has fully researched the Thuggish Splicer