Leave Ellie hanging after a job well done

Fully upgrade a weapon

Kill an enemy that is ignited, corroded, and recently got shocked.

Reach Interport warehouses.

Kill the Torantula with fire damage.

While in stealth, turn off the spotlight generator in Pittsburgh

Find a comic

Find one training manual

Kill a heavy enemy with fall damage.

Reach Watts-Rucker labs.

Score 3 headshots with a single shot from the ARC Cannon.

Skip the tutorial.