Max out all possible research

Fully research the Nitro Splicer

The player has taken a picture of Sander Cohen's corpse

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has defeated Andrew Ryan

The player has fully upgraded three weapons

The player has fully upgraded two weapons

The player has fully upgraded one weapon

The player has fully researched the Spider Splicer

The player has successfully invented at least one item

The player has purchased one slot in any Plasmid or Tonic track

The player has successfully hacked a vending machine