The player has either Harvested or Rescued every possible Little Sister

Fully research the Little Sister

The player has successfully invented all possible ammo types

The player has broken Fontaine's mind control

The player has defeated Andrew Ryan

Fully research the Houdini Splicer

The player has completed Sander Cohen's great masterpiece

The player has fully upgraded two weapons

The player has fully researched the Spider Splicer

Defeated the Invincible Empyrean Sentinel.

Gave the H-Source to Jack.

Successfully recovered the Override Key.

Get all other trophies