The player has defeated Atlas

Purchased every slot in all four Plasmid and Tonic tracks

The player has fully upgraded three weapons

Complete the game on any difficulty

Defeat the flight deck invader

Perform a kill with every firearm

Escape the mysterious structure under the mountain

The player has broken Fontaine's mind control

The player has purchased every slot in one of the Plasmid or Tonic tracks

Fully research the Houdini Splicer

Killed 50 bandits.

Repaired a piece of equipment.

You were reborn from the Well of Souls, and have escaped Allestar Tower.