The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has defeated Andrew Ryan

The player has taken a picture of Sander Cohen's corpse

Complete "Hail Sithis!"

Complete "Bound Until Death"

Complete "Elder Knowledge"

Join the College of Winterhold

The player has fully upgraded one weapon

The player has purchased one slot in any Plasmid or Tonic track

The player has defeated Peach Wilkins

The player has taken a Research Photo of the highest grade

The player has successfully hacked a safe