Open the wings of the Temple of the Fates

Collect all the Gorgon Eyes

Acquire Atlas Quake

Stone and Shatter 30 Enemies

Cross the collapsing Grapple Bridge

Acquire the Head of Euryale

Acquire the Golden Fleece

The player has taken a picture of Sander Cohen's corpse

The player has purchased every slot in one of the Plasmid or Tonic tracks

Complete act IV.

Kill 250 zombies using edged melee weapons.

Kill 50 zombies using a vehicle.

Kill 50 human enemies.