Complete the game on Survivor difficulty

Complete the game on Survivor difficulty without using a Vita-chamber

Complete the game on Hard difficulty without using a Vita-Chamber.

The player has defeated Atlas

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has successfully invented all possible ammo types

The player has either Harvested or Rescued every possible Little Sister

Fully upgrade five weapons

The player has entered Sander Cohen's personal quarters

Fully upgrade four weapons

Max out all possible research

The player has fully upgraded three weapons

The player has purchased every slot in one of the Plasmid or Tonic tracks