The player has broken Fontaine's mind control

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

Purchased every slot in all four Plasmid and Tonic tracks

The player has defeated Andrew Ryan

The player has purchased every slot in one of the Plasmid or Tonic tracks

Fully research the Little Sister

The player has completed Sander Cohen's great masterpiece

The player has fully upgraded two weapons

Hit the jackpot at a slot machine

The player has restored the forests of Arcadia

The player has fully upgraded one weapon

The player has fully researched the Thuggish Splicer