The player has broken Fontaine's mind control

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has entered Sander Cohen's personal quarters

The player has defeated Andrew Ryan

The player has successfully invented all possible ammo types

The player has fully upgraded one weapon

The player has successfully invented at least one item

The player has acquired at least one weapon upgrade

The player has taken at least one Research Photo of a Splicer

The player has defeated the crazed Dr. Steinman

The player has successfully hacked a safe

The player has successfully hacked a vending machine

The player has successfully hacked a security bot