Obtain the God Key.

Get through 10 code locks.

Gore 150 enemies.

Defeat the Übergarde in Brother 2.

Stealthily kill 50 enemies.

Revive or get revived 25 times.

Obtain 15 abilities.

Kill 20 drones.

Kill 75 enemies using the weapon type that's most effective against their shield type.

Pick up 250 loot supplies.

Obtain 5 abilities.

Purchase something from Baku the Voiceless in New Game+.