In the Main Campaign, completed Lighthouse.

The player has defeated Atlas

The player has become a Big Daddy

The player has broken Fontaine's mind control

Take at least one photo in every research group

The player has taken a picture of Sander Cohen's corpse

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has successfully invented all possible ammo types

Fully research the Houdini Splicer

The player has fully upgraded two weapons

The player has fully researched the Leadhead Splicer

The player has fully upgraded one weapon

The player has successfully invented at least one item