Defended yourself against Lamb's assault in the train station.

Found your way back into the ruins of Rapture.

The player has completed the game without harvesting any Little Sisters

Purchased every slot in all four Plasmid and Tonic tracks

The player has either Harvested or Rescued every possible Little Sister

Max out all possible research

Fully research the Rosie

The player has broken Fontaine's mind control

The player has entered Sander Cohen's personal quarters

Fully upgrade four weapons

The player has defeated Andrew Ryan

The player has fully researched the Leadhead Splicer