Find every audio diary

Successfully invent at least 100 items

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has broken Fontaine's mind control

The player has entered Sander Cohen's personal quarters

Max out all possible research

Purchased every slot in all four Plasmid and Tonic tracks

The player has defeated Andrew Ryan

The player has completed Sander Cohen's great masterpiece

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has successfully invented all possible ammo types

The player has fully researched the Spider Splicer

Fully research the Houdini Splicer