The player has successfully invented at least one item

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has fully upgraded one weapon

The player has fully researched the Thuggish Splicer

The player has defeated Peach Wilkins

The player has taken a Research Photo of the highest grade

The player has purchased one slot in any Plasmid or Tonic track

The player has successfully hacked a safe

The player has successfully hacked a turret

The player has performed at least one successful hack

The player has successfully completed the Welcome To Rapture Level

Found all 'Gangsters of the United States' cigarette cards